Seroflo (Fluticasone propionate and Salmeterol)

Seroflo is a medicine containing a combination of 2 active substances – Fluticasone propionate and Salmeterol. It is prescribed to overcome asthma and other bronchial dysfunctions.

Table of Contents

• What is it?
• How does it work?
• What is it used for?
• How to use?
• Side effects
• Dosage
• Seroflo and alcohol
• Seroflo and pregnancy
• Reviews

 

What is it?

Seroflo is a combined drug that contains salmeterol and fluticasone propionate, which have different mechanisms of action. Salmeterol prevents the occurrence of bronchospasm symptoms, fluticasone propionate enhances pulmonary function preventing the disease exacerbation.

Salmeterol is a selective, long-acting (up to 12 h) β2-adrenoreceptor agonist, which has a long side chain that binds to the outer domain of the receptor. The pharmacological properties of salmeterol provide more effective protection against histamine-induced bronchoconstriction and longer bronchodilation (lasting at least 12 hours) than short-acting β2-adrenergic receptor agonists.

Fluticasone – glucocorticosteroids for topical use with inhalation in the recommended doses with a pronounced anti-inflammatory and antiallergic effect in the lungs, which contributes to a decrease in clinical symptoms, a decrease in the frequency of bronchial asthma exacerbations.

How does it work?

Any inhalation corticosteroids can cause systemic effects, especially with prolonged use in high doses; however, the likelihood of such symptoms is much lower than in the treatment of oral glucocorticosteroids. Possible systemic reactions include Cushing syndrome, adrenal suppression, growth retardation in children and adolescents, reduced bone mineral density, cataracts, and glaucoma. Therefore, in the treatment of bronchial asthma, it is important to reduce the dose to the lowest dose, providing effective control over the disease.

What is it used for?

Basic therapy is associated with reversible airway obstruction (including bronchial asthma in children and adults) when it is appropriate to prescribe a combination therapy (bronchodilator and inhaled GCS):

• patients who receive maintenance therapy with β 2 long-acting adrenomimetic means and inhaled corticosteroids;
• patients who, while undergoing therapy with inhaled GCS, continue to have disease’s symptoms;
• patients who regularly use bronchodilators, and they are additionally prescribed therapy with inhaled corticosteroids.

Basic therapy of chronic obstructive pulmonary diseases, including chronic bronchitis and pulmonary emphysema.

How to use?

A steam inhaler is a method of treatment on the principle of evaporation of liquid into vapor (essential oil, decoction, infusion), which when inhaled enters the upper respiratory tract (trachea, nasopharynx). When using a steam inhaler follow the rules of operation, namely:

The medicine is poured into the tank (saline, water with essential oil, infusion), then the device is turned on.

When boiling, the device begins to release steam, the patient needs to inhale it for 5-15 minutes.

Side effects

Since the drug contains salmeterol and fluticasone propionate, its side effects are characteristic of each of these drugs. Their simultaneous use does not cause additional side effects.

Inhalation drugs can cause paradoxical bronchospasm, which must be immediately removed using a fast-acting inhaled bronchodilator. At the same time, it is necessary to immediately discontinue the use of this inhaler, evaluate the patient’s condition, conduct the necessary examination and, if necessary, prescribe therapy with other drugs.

Salmeterol can cause palpitations, headache, had a transient nature, or their severity decreased with regular treatment; rarely (in predisposed patients) – cardiac rhythm disturbance including atrial fibrillation.

Fluticasone propionate can cause voice hoarseness, candidiasis of the mouth and pharynx, paradoxical bronchospasm, in some cases – allergic skin reactions. There are separate reports of hypersensitivity reactions, manifested in the form of angioedema (mainly swelling of the face and oropharynx), respiratory symptoms (shortness of breath and/or bronchospasm) and very rarely anaphylactic reactions.

Adverse systemic effects include Cushing’s syndrome, Cushing-like symptoms, inhibition of adrenal cortex function, growth retardation in children and adolescents, osteoporosis, cataracts, and glaucoma.

There are isolated reports of cases of hyperglycemia, anxiety, sleep disturbances and behavioral changes, including hyperactivity and arousal (mainly in children).

Dosage

Seroflo is intended only for inhalation with the help of the powder inhaler. The drug should be used regularly, even in the absence of symptoms. During treatment, patients should be under the regular supervision of a physician in order to select the optimal dose and change the dose of the drug only on his recommendation. The initial dose is determined on the basis of fluticasone propionate dose, which is recommended for the treatment of a disease of a given severity. Then the initial dose of the drug should be gradually reduced to the minimum effective dose. Adults and adolescents aged 12 years and older are prescribed depending on the state of 1 capsule of Seroflo 50/100 mcg or Seroflo 50/250 mcg 2 times a day. For children aged 4 to 12 years, 1 capsule of Seroflo 50/100mcg is prescribed twice a day.

Seroflo and alcohol

There is no date concerning the application of Seroflo and alcohol.

Seroflo and pregnancy

The experience of using salmeterol and fluticasone propionate during pregnancy and lactation is insufficient, therefore, it is possible to prescribe the drug during these periods only if the intended benefit to the mother exceeds the potential risk to the fetus.

Reviews

Mollie Moran: “My asthma appeared long ago. I have undergone medical screening. I was prescribed Seroflo and was satisfied with almost an immediate result.”

Harrison Haynes: “I have become feeling better when using this asthma therapy. I have ordered this inhaler online and do recommend it.”

Zara Perkins: “Start treatment with Seroflo almost 4 months ago. The result is almost immediately observed. Buy it online and save money as I have done.”

Amy Brooks: “This is a means for coping with my respiratory problems. I buy this inhaler online. Thank you to the manufacturer of this effective drug.”